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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Fatty acid metabolism

The broad human network for fatty-acid synthesis, activation, elongation, desaturation and degradation. 232 reactions, from Reactome R-HSA-8978868.

  1. Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoAcis,cis-3,6-Dodecadienoyl-CoA → trans,cis-Lauro-2,6-dienoyl-CoA
  2. Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidationLIN-CoA + 3 FAD + 3 H2O + 3 NAD+ + 3 CoA-SH → cis,cis-3,6-Dodecadienoyl-CoA + 3 FADH2 + 3 NADH + 3 H+ + 3 Ac-CoA
  3. dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA4-cis-decenoyl-CoA + FAD → 2-trans-4-cis-decadienoyl-CoA + FADH2
  4. Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidationtrans,cis-Lauro-2,6-dienoyl-CoA + FAD + H2O + NAD+ + CoA-SH → 4-cis-decenoyl-CoA + FADH2 + NADH + Ac-CoA + H+
  5. Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA2-trans-4-cis-decadienoyl-CoA + NADH + H+ → 3-trans-decenoyl-CoA + NAD+
  6. Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA3-trans-decenoyl-CoA → tdec2-CoA
  7. PLA2G4A (cPLA2) hydrolyzes phosphatidylcholineH2O + AA-PC → AA + H+ + LysoPtdCho
  8. Arachidonate is oxidised to PGG2 by PTGS12 O2 + AA → PGG2
  9. PGG2 is reduced to PGH2 by PTGS1PGG2 + hydrogen donor → H2O + PGH2 + hydrogen acceptor
  10. Formation of fatty acid synthase (FAS) dimer2 FASN → FASN dimer
  11. OCTN2 / SLC22A5 transports CAR from extracellular space to cytosolCAR + Na+ → CAR + Na+
  12. CPT1A transfers PALM to CARCAR + PALM-CoA → CoA-SH + L-PCAR
  13. CPT2 converts acylcarnitine to acyl-CoACoA-SH + C8-C18 Acyl-CAR → CAR + C8-C18 Acyl-CoA
  14. pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesisBtn-ACACB:2Mn2+ polymer + ATP → Btn-p-S222-ACACB:2Mn2+ polymer + ADP + H+
  15. Exchange of acylcarnitine and carnitine across the inner mitochondrial membraneCAR + Acyl-CAR → CAR + Acyl-CAR
  16. Formation of Malonyl-CoA from Acetyl-CoA (liver)Ac-CoA + ATP + HCO3- → ADP + Pi + Mal-CoA + H+
  17. ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoAATP + CoA-SH + PALM → AMP + H2O + PALM-CoA + PPi
  18. Elongation of arachidonyl-CoA to docosatetraenoyl-CoAAA-CoA + Malonyl-CoA + 2 NADPH → DTA-CoA + CO2 + CoA-SH + H2O
  19. Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoAALA-CoA + O2 + 2 NADH → SDA-CoA + 2 H2O + 2 NAD+
  20. Activation of alpha-linolenic acid to alpha-linolenoyl-CoAALA + ATP + CoA-SH → ALA-CoA + PPi + adenosine 5'-monophosphate
  21. Translocation of tetracosahexaenoyl-CoA to peroxisomesATP + THA-CoA → ADP + PI + THA-CoA
  22. Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoASDA-CoA + Malonyl-CoA + 2 NADPH → ETA-CoA + H2O + CO2 + 2 NADP+ + CoA-SH
  23. Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoAETA-CoA + O2 + 2 NADH → EPA-CoA + 2 H2O + 2 NAD+
  24. Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoADPA-CoA + Malonyl-CoA + 2 NADPH → TPA-CoA + CO2 + CoA-SH + H2O + 2 NADP+
  25. Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoADGL-CoA + O2 + 2 NADH → AA-CoA + 2 H2O + 2 NAD+
  26. Translocation of tetracosapentaenoyl-CoA to peroxisomesATP + TPA-CoA → ADP + TPA-CoA + Pi
  27. Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoAGLA-CoA + Malonyl-CoA + 2 NADPH → DGL-CoA + H2O + CO2 + 2 NADP+ + CoA-SH
  28. Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoADTA-CoA + Malonyl-CoA + 2 NADPH → TTA-CoA + CO2 + CoA-SH + H2O
  29. Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoALA-CoA + O2 + 2 NADH → GLA-CoA + 2 H2O + 2 NAD+
  30. Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoATTA-CoA + O2 + 2 NADH → TPA-CoA + 2 H2O + 2 NAD+
  31. Activation of linoleic acid to linoleoyl-CoALINA + ATP + CoA-SH → LA-CoA + PPi + adenosine 5'-monophosphate
  32. Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoATPA-CoA + O2 + 2 NADH → THA-CoA + 2 H2O + 2 NAD+
  33. Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoAEPA-CoA + Malonyl-CoA + 2 NADPH → DPA-CoA + CO2 + CoA-SH + H2O + 2 NADP+
  34. Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoATPA-CoA → DPA
  35. Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoAdelta2-THA-CoA + H2O → 1-3-hydroxy-THA-CoA
  36. Conversion of DHA-CoA to docosahexaenoic acid (DHA)DHA-CoA + H2O → DHA + CoA-SH
  37. Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA1-3-hydroxy-THA-CoA → 1-3-oxo-THA-CoA
  38. Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)1-3-oxo-THA-CoA + CoA-SH → DHA-CoA + propionyl CoA
  39. Translocation of DPA to the ERDPA → DPA
  40. Retranslocation of DHA back to ERDHA → DHA
  41. Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoATHA-CoA + O2 → delta2-THA-CoA + H2O2
  42. Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase1-3-oxo-THA-CoA + CoA-SH → DHA-CoA + Ac-CoA
  43. CYP4F2, 4F3 20-hydroxylate LTB4LTB4 + NADPH + H+ + O2 → 20OH-LTB4 + H2O + NADP+
  44. PGH2 is reduced to PGF2a by AKR1C3PGH2 + NADPH + H+ → PGF2a + NADP+
  45. PGJ2 is isomerised to delta12-PGJ2PGJ2 → delta12-PGJ2
  46. LTB4 is oxidised to 12-oxoLTB4 by PTGR1LTB4 + NADP+ → 12-oxoLTB4 + NADPH + H+
  47. Delta12-PGJ2 is dehydrated to 15d-PGJ2delta12-PGJ2 → 15d-PGJ2 + H2O
  48. PGH2 is reduced to PGF2a by FAM213BPGH2 + TXN-S2H2 → PGF2a + TXN-S2
  49. PGH2 is degraded to 12S-HHT and MDA by TBXAS1PGH2 → 12S-HHT + MDA
  50. PGD2 is reduced to 11-epi-PGF2a by AKRIC3PGD2 + H+ + NADPH → 11epi-PGF2a + NADP+
  51. PGI2 is hydrolysed to 6k-PGF1aPGI2 + H2O → 6k-PGF1a
  52. PGH2 is isomerised to PGD2 by PTGDSPGH2 → PGD2
  53. PGE2 is converted to PGF2a by CBR1PGE2 + NADPH + H+ → PGF2a + NADP+
  54. PGE2 is dehydrated to PGA2PGE2 → H2O + PGA2
  55. PGH2 is isomerised to PGE2 by PTGESPGH2 → PGE2
  56. PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGDPGD2/E2/F2a + NAD+ → 15k-PGD2,15k-PGE2,15k-PGF2a + NADH + H+
  57. PGA2 is isomerised to PGC2PGA2 → PGC2
  58. PGA2 is dehydrated to 15d-PGA2PGA2 → 15d-PGA2 + H2O
  59. PGD2 is dehydrated to 15d-PGD2PGD2 → 15d-PGD2 + H2O
  60. 15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR115k-PGE2,15k-PGF2a + NADPH + H+ → dhk-PGE2,dhk-PGF2a + NADP+
  61. PGH2 is isomerised to PGD2 by HPGDSPGH2 → PGD2
  62. TXB2 is converted to 11dh-TXB2 by TXDHTXB2 + NAD+ → 11dh-TXB2 + NADH + H+
  63. PGD2 is dehydrated to PGJ2PGD2 → PGJ2 + H2O
  64. PGC2 is isomerised to PGB2PGC2 → PGB2
  65. 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F320OH-LTB4 + NADPH + H+ + O2 → 20cho-LTB4 + NADP+ + 2 H2O
  66. EXA4 is converted to EXC4 by LTC4SEXA4 + GSH → EXC4
  67. 5S-HETE is oxidised to 5-oxoETE by 5-HEDH5S-HETE + NADP+ → 5-oxoETE + NADPH + H+
  68. 15S-HETE is oxidised to 15-oxoETE by 15-HEDH15S-HETE + NAD(P)+ → 15-oxoETE + NAD(P)H + H+
  69. 20cooh-LTB4 is converted to 18cooh-LTB420cooh-LTB4 → 18cooh-LTB4
  70. 15S-HpETE is reduced to 15S-HETE by GPX1/2/415S-HpETE + 2 GSH → 15S-HETE + GSSG + H2O
  71. 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F320cho-LTB4 + NADPH + H+ + O2 → 20cooh-LTB4 + NADP+ + H2O
  72. Arachidonate is converted to HXA3/B3 by ALOX12AA + O2 → HXA3/B3
  73. Arachidonate is hydroxylated to 16-HETE by CYP(1)AA + O2 + NADPH + H+ → NADP+ + H2O + 16-HETE
  74. Arachidonate is hydroxylated to 19-HETE by CYP(2)AA + O2 + NADPH + H+ → 19-HETE + NADP+ + H2O
  75. EXD4 is converted to EXE4 by DPEPEXD4 + H2O → EXE4 + Gly
  76. Arachidonate is epoxidated to 5,6-EET by CYP(4)AA + O2 + NADPH + H+ → 5,6-EET + NADP+ + H2O
  77. Arachidonate is epoxidated to 8,9-EET by CYP(5)AA + O2 + NADPH + H+ → NADP+ + H2O + 8,9-EET
  78. Arachidonate is hydroxylated to 20-HETE by CYP(3)AA + O2 + NADPH + H+ → 20-HETE + NADP+ + H2O
  79. EXC4 is converted to EXD4 by GGTEXC4 → EXD4 + L-Glu
  80. 5S-HpETE is reduced to 5S-HETE by GPX1/2/45S-HpETE + 2 GSH → 5S-HETE + GSSG + H2O
  81. Arachidonate is converted to 12-oxoETE by ALOX12AA → 12-oxoETE
  82. HXA3/B3 is hydrolysed to TrXA3/B3 by HXEHHXA3/B3 + H2O → TrXA3/B3
  83. Arachidonate is oxidised to 12R-HpETE by ALOX12BAA + O2 → 12R-HpETE
  84. Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2AA + O2 + NADPH + H+ → 15R-HETE + NADP+ + H2O
  85. 12R-HpETE is reduced to 12R-HETE by GPX1/2/412R-HpETE + 2 GSH → 12R-HETE + GSSG + H2O
  86. 5,6-EET is hydrolysed to 5,6-DHET by EPHX2H2O + 5,6-EET → 5,6-DHET
  87. LTA4 is hydrolysed to 6t-/6t,12epi-LTB4LTA4 + H2O → 6t/6t,12epi-LTB4
  88. Arachidonate is oxidised to 12S-HpETE by ALOX12/15AA + O2 → 12S-HpETE
  89. 20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH20cho-LTB4 + NADPH + H+ + O2 → 20cooh-LTB4 + NADP+ + H2O
  90. 12S-HpETE is reduced to 12S-HETE by GPX1/2/412S-HpETE + 2 GSH → 12S-HETE + GSSG + H2O
  91. Arachidonate is oxidised to 15S-HpETE by ALOX15/15BAA + O2 → 15S-HpETE
  92. LTA4 is converted to EXA4 by ALOX15LTA4 → EXA4
  93. PGH2 diffuses from the endoplasmic reticulum lumen to the cytosolPGH2 → PGH2
  94. PGG2 is reduced to PGH2 by PTGS2PGG2 + hydrogen donor → H2O + PGH2 + hydrogen acceptor
  95. PTGS2 dimer binds PTGS2 inhibitorsPTGS2 dimer + PTGS2 inhibitors → PTGS2 dimer:PTGS2 inhibitors
  96. Arachidonate is oxidised to PGG2 by PTGS22 O2 + AA → PGG2
  97. ASA- acetylates PTGS1PTGS1 dimer + ASA- → Ac-PTGS1 dimer + ST
  98. ASA- acetylates PTGS2PTGS2 dimer + ASA- → Ac-PTGS2 dimer + ST
  99. Prostaglandin E synthase isomerizes PGH2 to PGE2PGH2 → PGE2
  100. Arachidonate is oxidised to 5S-HpETE by ALOX5AA + O2 → 5S-HpETE
  101. LTD4 is converted to LTE4 by DPEP1/2LTD4 + H2O → LTE4 + Gly
  102. GGT1, 5 dimers hydrolyse LTC4 to LTD4LTC4 + H2O → LTD4 + L-Glu
  103. LTA4 is converted to LTC4 by LTC4SLTA4 + GSH → LTC4
  104. 5S-HpETE is dehydrated to LTA4 by ALOX55S-HpETE → LTA4 + H2O
  105. LTC4 is exported from the cytosol by ABCC1LTC4 + ATP + H2O → H+ + Pi + LTC4 + ADP
  106. LTA4 is hydolysed to LTB4 by LTA4HLTA4 + H2O → LTB4
  107. formyl-CoA + H2O => formate + CoASHFOR-CoA + H2O → CoA-SH + HCOOH
  108. ALDH3A2-2 oxidizes pristanal to pristanateNAD+ + Pristanal + H2O → pristanate + NADH + 2 H+
  109. 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA3S2HPhy-CoA → Pristanal + FOR-CoA
  110. phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphateATP + CoA-SH + Phytanate → AMP + Phytanoyl-CoA + PPi
  111. pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphateATP + CoA-SH + pristanate → AMP + (2R) Pristanoyl-CoA + PPi
  112. phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2Phytanoyl-CoA + 2OG + O2 → 3S2HPhy-CoA + SUCCA + CO2
  113. PMP34-mediated exchange of cytosolic ATP for peroxisomal AMPAMP + ATP → AMP + ATP
  114. ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA(2S) Pristanoyl-CoA + O2 → trans-2,3-dehydropristanoyl-CoA + H2O2
  115. (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)(2S) Pristanoyl-CoA + O2 → trans-2,3-dehydropristanoyl-CoA + H2O2
  116. Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA(2R) Pristanoyl-CoA → (2S) Pristanoyl-CoA
  117. trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoAtrans-2,3-dehydropristanoyl-CoA + H2O → 3-hydroxypristanoyl-CoA
  118. 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+3-hydroxypristanoyl-CoA + NAD+ → 3-ketopristanoyl-CoA + NADH + H+
  119. 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA3-ketopristanoyl-CoA + CoA-SH → 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA
  120. 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA3-ketohexacosanoyl-CoA + CoA-SH → tetracosanoyl-CoA + Ac-CoA
  121. HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA3-hydroxyhexacosanoyl-CoA + NAD+ → 3-ketohexacosanoyl-CoA + NADH + H+
  122. HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoAtrans-2,3-dehydrohexacosanoyl-CoA + H2O → 3-hydroxyhexacosanoyl-CoA
  123. ACOX1 oxidizes C26:0 CoAC26:0 CoA + O2 → trans-2,3-dehydrohexacosanoyl-CoA + H2O2
  124. Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA4,8,12-trimethyltridecanoyl-CoA → 4,8-dimethylnonanoyl-CoA
  125. 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH4,8-dimethylnonanoyl-CoA + CAR → 4,8-dimethylnonanoylcarnitine + CoA-SH
  126. propionyl-CoA + carnitine => propionylcarnitine + CoASHpropionyl CoA + CAR → Propionylcarnitine + CoA-SH
  127. acetyl-CoA + carnitine => acetylcarnitine + CoASHAc-CoA + CAR → ACAR + CoA-SH
  128. Beta-oxidation of tetradecenoyl-CoA to octanoyl-CoA8 CoA-SH + 8 H2O + 8 NAD+ + 8 O2 + tetracosanoyl-CoA → 8 Ac-CoA + 8 H+ + 8 H2O2 + 8 NADH + Octanoyl-CoA
  129. acetyl-CoA + H2O => acetate + CoASH + H+Ac-CoA + H2O → CH3COO- + CoA-SH + H+
  130. Peroxisomal uptake of very long-chain fatty acyl CoAVLCFA-CoA + 2 H2O + ATP → VLCFA + ADP + CoA-SH + 2 H+
  131. SLC27A1 transports arachidonate across the ER membraneAA → AA
  132. ALOX5 is phosphorylated by MAPKAP2ALOX5:Ca2+:Fe2+ + ATP → p-S272-ALOX5:Ca2+:Fe2+ + ADP + H+
  133. TXA2 is hydrolysed to TXB2TXA2 + H2O → TXB2
  134. ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoAAA-CoA + Mal-CoA + H+ → 3ODCT-CoA + CoA-SH + CO2
  135. ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoAPALM-CoA + Mal-CoA + H+ → 3OOD-CoA + CoA-SH + CO2
  136. ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoAICS-CoA + Mal-CoA + H+ → CoA-SH + CO2 + 3ODC-CoA
  137. HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA3OOD-CoA + NADPH + H+ → 3HODC-CoA + NADP+
  138. ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoATCS-CoA + Mal-CoA + H+ → 3OHC-CoA + CoA-SH + CO2
  139. TECR,TECRL dehydrogenate TOD-CoA to ST-CoATOD-CoA + NADPH + H+ → ST-CoA + NADP+
  140. ACSL3,4 ligate CoA to AA to form AA-CoAAA + ATP + CoA-SH → AA-CoA + AMP + PPi + H2O
  141. OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer2 H2O + decanoyl-FASN dimer → 2 DECA + FASN dimer + 2 H+
  142. PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoAVLC3HA-CoA → 2,3-TE-CoA + H2O
  143. Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoAMCFA-CoA, LCFA-CoA + H2O → MCFA, LCFA + CoA-SH + H+
  144. Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoAMCFA-CoA, LCFA-CoA + H2O → MCFA, LCFA + CoA-SH + H+
  145. PPT2 hydrolyses PALMCoA to PALMPALM-CoA + H2O → PALM + CoA-SH + H+
  146. ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoAMCFA-CoA, LCFA-CoA + H2O → MCFA, LCFA + CoA-SH + H+
  147. PPT1 hydrolyses palmitoylated proteinsPALM:protein + H2O → PALM + protein + H+
  148. SCD desaturates ST-CoA to OLE-CoAST-CoA + 2 H+ + O2 + 2 Fe(2+)Cb5 → OLE-CoA + 2 Fe(3+)Cb5 + 2 H2O
  149. FAAH hydrolyses AEA to AA and ETAAEA + H2O → AA + ETA
  150. FAAH2 hydrolyses AEA to AA and ETAAEA + H2O → AA + ETA
  151. ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoAVLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi
  152. ACAD10 dehydrogenates S-2MPDA-CoAS-2MPDA-CoA + FAD → S-2MDPDA-CoA + FADH2
  153. ACAD11 dehydrogenates BH-CoABH-CoA + FAD → DHB-CoA + FADH2
  154. ACSF2 ligates CoA-SH to MCFAMCFA + ATP + CoA-SH → MCFA-CoA + AMP + PPi
  155. ACSF3 ligates CoA-SH to VLCFAVLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi
  156. AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax estersARACOH + Acyl-CoA → arachidyl ester + CoA-SH
  157. DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoANADPH + H+ + (2E,4E)-dienoyl-CoA → NADP+ + 4,5-saturated-(3E)-enoyl-CoA(4-)
  158. HAO2 tetramer oxidises 2OH-PALM2OH-PALM + O2 → 2oxo-PALM + H2O2
  159. EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoAtrans-2,3-dehydrohexacosanoyl-CoA + H2O → 3-hydroxyhexacosanoyl-CoA
  160. EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA3-hydroxyhexacosanoyl-CoA + NAD+ → 3-ketohexacosanoyl-CoA + NADH + H+
  161. NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANTCoA-SH + H2O → PPANT + PAP + 2 H+
  162. ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA3Z-octenoyl-CoA → 2E-octenoyl-CoA
  163. PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA2E-phytenoyl-CoA + H+ + NADPH → NADP+ + Phytanoyl-CoA
  164. NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANTacyl-CoA + H2O → acyl-PPANT + PAP + 2 H+
  165. MUT isomerises L-MM-CoA to SUCC-CoAL-MM-CoA → SUCC-CoA
  166. D-methylmalonyl-CoA L-methylmalonyl-CoAMEMA-CoA → L-MM-CoA
  167. propionyl-CoA + CO2 + ATP D-methylmalonyl-CoA + ADP + orthophosphatePROP-CoA + ATP + HCO3- → MEMA-CoA + ADP + Pi + H+
  168. ACLY tetramer transforms CIT to Ac-CoACIT + CoA-SH + ATP → Ac-CoA + ADP + OA + Pi
  169. Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoAAc-CoA + ATP + HCO3- → ADP + Pi + Mal-CoA + H+
  170. Conversion of malonyl-CoA and acetyl-CoA to palmitateAc-CoA + 7 Mal-CoA + 14 NADPH + 14 H+ → PALM + 7 CO2 + 14 NADP+ + 8 CoA-SH + 6 H2O
  171. PTGIS, CYP8A1 isomerise PGH2 to PGI2PGH2 → PGI2
  172. TBXAS1 isomerises PGH2 to TXA2PGH2 → TXA2
  173. (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+HNAD+ + (S)-3-Hydroxydodecanoyl-CoA → NADH + H+ + 3-Oxododecanoyl-CoA
  174. 2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoAH2O + 2-trans-Dodecenoyl-CoA → (S)-3-Hydroxydodecanoyl-CoA
  175. lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2FAD + LAU-CoA + H+ → FADH2 + 2-trans-Dodecenoyl-CoA
  176. 3-Oxotetradecanoyl-CoA+CoA-SH => Lauroyl-CoA + acetyl-CoA3-Oxotetradecanoyl-CoA + CoA-SH → LAU-CoA + Ac-CoA
  177. myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2FAD + MYS-CoA + H+ → FADH2 + trans-Tetradec-2-enoyl-CoA
  178. trans-Tetradec-2-enoyl-CoA+H2O => (S)-3-Hydroxytetradecanoyl-CoAH2O + trans-Tetradec-2-enoyl-CoA → (S)-3-Hydroxytetradecanoyl-CoA
  179. (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+HNAD+ + (S)-3-Hydroxytetradecanoyl-CoA → NADH + H+ + 3-Oxotetradecanoyl-CoA
  180. palmitoyl-CoA+FAD => trans-Hexadec-2-enoyl-CoA+FADH2PalmCoA + FAD + H+ → FADH2 + trans-Hexadec-2-enoyl-CoA
  181. trans-Hexadec-2-enoyl-CoA+H2O => (S)-3-Hydroxyhexadecanoyl-CoAtrans-Hexadec-2-enoyl-CoA + H2O → (S)-3-Hydroxyhexadecanoyl-CoA
  182. (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H(S)-3-Hydroxyhexadecanoyl-CoA + NAD+ → NADH + 3-Oxopalmitoyl-CoA + H+
  183. 3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA3-Oxopalmitoyl-CoA + CoA-SH → MYS-CoA + Ac-CoA
  184. 3-Oxododecanoyl-CoA+CoA-SH => Decanoyl-CoA + acetyl-CoA3-Oxododecanoyl-CoA + CoA-SH → DEC-CoA + Ac-CoA
  185. (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+HNAD+ + 3HB-CoA → NADH + H+ + ACA-CoA
  186. Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoAH2O + Crotonoyl-CoA → 3HB-CoA
  187. Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2FAD + BT-CoA + H+ → FADH2 + Crotonoyl-CoA
  188. 3-Oxohexanoyl-CoA+CoA-SH => Butanoyl-CoA + acetyl-CoA3-Oxohexanoyl-CoA + CoA-SH → Ac-CoA + BT-CoA
  189. (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+HNAD+ + (S)-Hydroxyhexanoyl-CoA → NADH + H+ + 3-Oxohexanoyl-CoA
  190. trans-Hex-2-enoyl-CoA+H2O (S)-Hydroxyhexanoyl-CoAH2O + trans-Hex-2-enoyl-CoA → (S)-Hydroxyhexanoyl-CoA
  191. Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2FAD + HX-CoA + H+ → FADH2 + trans-Hex-2-enoyl-CoA
  192. 3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA3-Oxooctanoyl-CoA + CoA-SH → HX-CoA + Ac-CoA
  193. (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+HNAD+ + (S)-Hydroxyoctanoyl-CoA → NADH + H+ + 3-Oxooctanoyl-CoA
  194. trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoAH2O + trans-Oct-2-enoyl-CoA → (S)-Hydroxyoctanoyl-CoA
  195. Octanoyl-CoA+FAD => trans-Oct-2-enoyl-CoA+FADH2FAD + Octanoyl-CoA + H+ → FADH2 + trans-Oct-2-enoyl-CoA
  196. 3-Oxodecanoyl-CoA+CoA-SH => Octanoyl-CoA + acetyl-CoA3-Oxodecanoyl-CoA + CoA-SH → Octanoyl-CoA + Ac-CoA
  197. (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+HNAD+ + (S)-Hydroxydecanoyl-CoA → NADH + H+ + 3-Oxodecanoyl-CoA
  198. trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoAH2O + tdec2-CoA → (S)-Hydroxydecanoyl-CoA
  199. Decanoyl-CoA+FAD => trans-Dec-2-enoyl-CoA+FADH2FAD + DEC-CoA + H+ → FADH2 + tdec2-CoA
  200. SCD5 desaturates ST-CoA to OLE-CoAST-CoA + 2 H+ + O2 + 2 Fe(2+)Cb5 → OLE-CoA + 2 Fe(3+)Cb5 + 2 H2O
  201. DBI, ACBD7 bind MCFA-CoA and LCFA-CoADBI, (ACBD7) + MCFA-CoA, LCFA-CoA → DBI,ACBD7:MCFA-CoA,LCFA-CoA
  202. ACBD4,5 bind MCFA-CoA and LCFA-CoAACBD5,(ACBD4) + MCFA-CoA, LCFA-CoA → ACBD4,5:LCFA-CoA, MCFA-CoA
  203. ACBD6 binds LCFA-CoAACBD6 + LCFA-CoA → ACBD6:LCFA-CoA
  204. 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACPNADPH + H+ + 3OA-ACP → NADP+ + 3HA-ACP
  205. MID1IP1 binds THRSPMID1IP1 + THRSP → MID1IP1:THRSP
  206. ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SHAc-CoA + acyl-CoA → 3OA-CoA + CoA-SH
  207. ACSM3,ACSM6 ligate CoA to BUTBUT + ATP + CoA-SH → BT-CoA + AMP + PPi
  208. SLC27A3 ligates CoA-SH to VLCFAATP + CoA-SH + VLCFA → VLCFA-CoA + AMP + PPi
  209. Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoAAc-CoA + ATP + HCO3- → ADP + Pi + Mal-CoA + H+
  210. PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE5-HETEL + H2O → 5-HETE
  211. MCAT transfers Mal from Mal-CoA to NDUFAB1Malonyl-CoA + NDUFAB1 → Mal-PPANT-S112-NDUFAB1 + CoA-SH
  212. ALOXE3 isomerises 12R-HpETE to HXA312R-HpETE → HXA3
  213. CAR translocates from the cytosol to the mitochondrial intermembrane spaceCAR → CAR
  214. MECR dimer reduces tdec2-CoA to DEC-CoAtdec2-CoA + NADPH + H+ → DEC-CoA + NADP+
  215. RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA3HA-CoA → t2E-CoA + H2O
  216. PTGS1 dimer binds PTGS1 InhibitorsPTGS1 dimer + PTGS1 Inhibitors → PTGS1 dimer:PTGS1 Inhibitors
  217. ALOX5 binds ALOX5 inhibitorsALOX5:ALOX5AP:LTC4S + ALOX5 inhibitors → ALOX5:ALOX5 inhibitors
  218. PTGS2 dimer binds PTGS inhibitorsPTGS2 dimer + PTGS inhibitors → PTGS2 dimer:PTGS inhibitors
  219. PTGS1,2 dimers bind PTGS InhibitorsPTGS1 dimer + PTGS inhibitors + PTGS2 dimer → PTGS1 dimer:PTGS Inhibitors + PTGS2 dimer:PTGS inhibitors
  220. SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoAbempedoic acid + CoA-SH + ATP → ETC-1002-CoA + AMP + PPi
  221. ACLY tetramer binds ETC-1002-CoAACLY tetramer + ETC-1002-CoA → ACLY tetramer:ETC-1002-CoA
  222. malonyl-CoA is decarboxylated to acetyl-CoA in peroxisomeMalonyl-CoA + H+ → Ac-CoA + CO2
  223. CPT1B transfers PALM to CARCAR + PALM-CoA → CoA-SH + L-PCAR
  224. SLC27A2-mediated ligation of peroxisomal fatty acid and CoASHATP + CoA-SH + VLCFA → AMP + PPi + VLCFA-CoA
  225. 8,9-EET is hydrolysed to 8.9-DHET by EPHX2H2O + 8,9-EET → 8,9-DHET
  226. Arachidonate is epoxidated to 11,12-EET by CYP(5)AA + O2 + NADPH + H+ → NADP+ + H2O + 11,12-EET
  227. 11,12-EET is hydrolysed to 11,12-DHET by EPHX2H2O + 11,12-EET → 11,12-DHET
  228. Arachidonate is hydroxylated to 17-HETE by CYP(1)AA + O2 + NADPH + H+ → NADP+ + H2O + 17-HETE
  229. Arachidonate is hydroxylated to 18-HETE by CYP(1)AA + O2 + NADPH + H+ → NADP+ + H2O + 18-HETE
  230. 14,15-EET is hydrolysed to 14,15-DHET by EPHX2H2O + 14,15-EET → 14,15-DHET
  231. Arachidonate is epoxidated to 14,15-EET by CYP(5)AA + O2 + NADPH + H+ → NADP+ + H2O + 14,15-EET
  232. SLC25A20 exports excess acyl-CARAcyl-CAR + CAR → Acyl-CAR + CAR