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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Arachidonate is oxidised to 15S-HpETE by ALOX15/15B

AA + O2 → 15S-HpETE

Reactome: R-HSA-2162002
Compartment: cytosol
Rhea: RHEA:16870

Inputs

AACHEBI:32395, C20H31O2, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

15S-HpETECHEBI:57446, C20H31O4, cytosol

Catalysed by

arachidonate 15-lipoxygenase activity of ALOX15/15B [cytosol]EC 1.13.11.33

Literature

Expression of 15-lipoxygenase type-1 in human mast cells Biochim Biophys Acta, 2007
Overexpression, purification and characterization of human recombinant 15-lipoxygenase Biochim Biophys Acta, 1993
Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes Eur J Biochem, 1991
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells J Biol Chem, 2002
Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation Biochemistry, 2008