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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA

GLA-CoA + Malonyl-CoA + 2 NADPH → DGL-CoA + H2O + CO2 + 2 NADP+ + CoA-SH

Reactome: R-HSA-2046094
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

GLA-CoACHEBI:15508, C39H64N7O17P3S, endoplasmic reticulum lumen
Malonyl-CoACHEBI:57384, C24H33N7O19P3S, endoplasmic reticulum lumen
2 NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen

Outputs

DGL-CoACHEBI:27979, C41H68N7O17P3S, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
CO2CHEBI:16526, CO2, endoplasmic reticulum lumen
2 NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen

Catalysed by

fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]EC 2.3.1.199

Literature

Metabolism of gammalinolenic acid in human neutrophils J Immunol, 1996
Importance of dietary gamma-linolenic acid in human health and nutrition J Nutr, 1998
Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids Biochem J, 2000