acetyl-CoA + H2O => acetate + CoASH + H+
Ac-CoA + H2O → CH3COO- + CoA-SH + H+
- Reactome
- R-HSA-390304
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:20290
Inputs
- Ac-CoACHEBI:57288, C23H34N7O17P3S, peroxisomal matrix
- H2OCHEBI:15377, H2O, peroxisomal matrix
Outputs
- CH3COO-CHEBI:30089, C2H3O2, peroxisomal matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, peroxisomal matrix
- H+CHEBI:15378, H, peroxisomal matrix
Catalysed by
- acetyl-CoA hydrolase activity of ACOT8 [peroxisomal matrix]EC 3.1.2.1; UniProt O14734
Literature
- Identification of peroxisomal acyl-CoA thioesterases in yeast and humans J Biol Chem, 1999
- Biochemistry of mammalian peroxisomes revisited Annu Rev Biochem, 2006