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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX5 is phosphorylated by MAPKAP2

ALOX5:Ca2+:Fe2+ + ATP → p-S272-ALOX5:Ca2+:Fe2+ + ADP + H+

Reactome: R-HSA-429016
Compartment: cytosol
Rhea: RHEA:17990

Inputs

ALOX5:Ca2+:Fe2+R-HSA-2237880, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

p-S272-ALOX5:Ca2+:Fe2+R-HSA-265277, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]EC 2.7.11.1; UniProt P49137

Literature

5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases Proc Natl Acad Sci U S A, 2000
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2) J Biol Chem, 2002