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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LTA4 is hydrolysed to 6t-/6t,12epi-LTB4

LTA4 + H2O → 6t/6t,12epi-LTB4

Reactome: R-HSA-2161962
Compartment: cytosol
Rhea: None recorded

Inputs

LTA4CHEBI:57463, C20H29O3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

6t/6t,12epi-LTB4R-ALL-2161801, cytosol

Literature

Inhibition of calcium ionophore-stimulated leukotriene generation from intact human neutrophils by captopril Res Commun Mol Pathol Pharmacol, 1999
Metabolism of leukotrienes by adult and fetal human lungs Exp Lung Res, 1985