ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA
(2S) Pristanoyl-CoA + O2 → trans-2,3-dehydropristanoyl-CoA + H2O2
- Reactome
- R-HSA-389889
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:40460
Inputs
- (2S) Pristanoyl-CoACHEBI:77099, C40H68N7O17P3S, peroxisomal matrix
- O2CHEBI:15379, O2, peroxisomal matrix
Outputs
- trans-2,3-dehydropristanoyl-CoACHEBI:77293, C40H66N7O17P3S, peroxisomal matrix
- H2O2CHEBI:16240, H2O2, peroxisomal matrix
Catalysed by
- pristanoyl-CoA oxidase activity of ACOX2:FAD, ACOXL:FAD [peroxisomal matrix]EC 1.3.3
Literature
- The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney J Biol Chem, 1993
- Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome Proc Natl Acad Sci U S A, 1996