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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

5S-HpETE is dehydrated to LTA4 by ALOX5

5S-HpETE → LTA4 + H2O

Reactome: R-HSA-266051
Compartment: cytosol · nuclear envelope
Rhea: RHEA:17962

Inputs

5S-HpETECHEBI:57450, C20H31O4, cytosol

Outputs

LTA4CHEBI:57463, C20H29O3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

oxidoreductase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]EC 1

Literature

Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells J Biol Chem, 1988
Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase Proc Natl Acad Sci U S A, 1987
Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities Proc Natl Acad Sci U S A, 1986