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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA

3OOD-CoA + NADPH + H+ → 3HODC-CoA + NADP+

Reactome: R-HSA-548818
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:35301

Inputs

3OOD-CoACHEBI:71407, C39H64N7O18P3S, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

3HODC-CoACHEBI:71408, C39H66N7O18P3S, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

very-long-chain 3-oxoacyl-CoA reductase activity of HSD17B3,12 [endoplasmic reticulum membrane]EC 1.1.1.330

Literature

Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3 Nat Genet, 1994
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade J Biol Chem, 2003