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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2

AA + O2 + NADPH + H+ → 15R-HETE + NADP+ + H2O

Reactome: R-HSA-2161951
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:52497

Inputs

AACHEBI:32395, C20H31O2, cytosol
O2CHEBI:15379, O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

15R-HETECHEBI:78837, C20H31O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]EC 1.13

Literature

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions Proc Natl Acad Sci U S A, 1995