Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H

NAD+ + (S)-3-Hydroxytetradecanoyl-CoA → NADH + H+ + 3-Oxotetradecanoyl-CoA

Reactome: R-HSA-77283
Compartment: mitochondrial matrix
Rhea: RHEA:31168

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
(S)-3-Hydroxytetradecanoyl-CoACHEBI:62614, C35H58N7O18P3S, mitochondrial matrix

Outputs

NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
3-Oxotetradecanoyl-CoACHEBI:62543, C35H56N7O18P3S, mitochondrial matrix

Catalysed by

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of Trifunctional Protein [mitochondrial matrix]EC 1.1.1.35

Literature

Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria. Biochem Biophys Res Commun, 1992