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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters

ARACOH + Acyl-CoA → arachidyl ester + CoA-SH

Reactome: R-HSA-5696424
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: RHEA:38444

Inputs

ARACOHCHEBI:75627, C20H42O, endoplasmic reticulum lumen
Acyl-CoACHEBI:58342, C22H31N7O17P3SR, endoplasmic reticulum lumen

Outputs

arachidyl esterCHEBI:10036, CO2R2, endoplasmic reticulum lumen
CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen

Catalysed by

long-chain-alcohol O-fatty-acyltransferase activity of AWAT1 [endoplasmic reticulum membrane]EC 2.3.1.75; UniProt Q58HT5

Literature

Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily J. Biol. Chem., 2005