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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACLY tetramer transforms CIT to Ac-CoA

CIT + CoA-SH + ATP → Ac-CoA + ADP + OA + Pi

Reactome: R-HSA-75848
Compartment: cytosol
Rhea: RHEA:21162

Inputs

CITCHEBI:16947, C6H5O7, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
OACHEBI:16452, C4H2O5, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

ATP citrate synthase activity of ACLY tetramer [cytosol]EC 2.3.3.8

Literature

Cloning and expression of a human ATP-citrate lyase cDNA Eur J Biochem, 1992
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth Mol. Cell, 2013
Cytosolic functions of MORC2 in lipogenesis and adipogenesis Biochim. Biophys. Acta, 2014
Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle Protein Cell, 2023
Regulation and function of the mammalian tricarboxylic acid cycle J Biol Chem, 2023
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan Antioxidants (Basel), 2021