Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA

H2O + Crotonoyl-CoA → 3HB-CoA

Reactome: R-HSA-77314
Compartment: mitochondrial matrix
Rhea: RHEA:26560

Inputs

H2OCHEBI:15377, H2O, mitochondrial matrix
Crotonoyl-CoACHEBI:57332, C25H36N7O17P3S, mitochondrial matrix

Outputs

3HB-CoACHEBI:57316, C25H38N7O18P3S, mitochondrial matrix

Catalysed by

enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]EC 4.2.1.17

Literature

Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase. J Biol Chem, 1956