SCD desaturates ST-CoA to OLE-CoA
ST-CoA + 2 H+ + O2 + 2 Fe(2+)Cb5 → OLE-CoA + 2 Fe(3+)Cb5 + 2 H2O
- Reactome
- R-HSA-5690565
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- RHEA:19722
Inputs
- ST-CoACHEBI:57394, C39H66N7O17P3S, cytosol
- 2 H+CHEBI:15378, H, cytosol
- O2CHEBI:15379, O2, cytosol
- 2 Fe(2+)Cb5CHEBI:16518, cytosol
Outputs
- OLE-CoACHEBI:57387, C39H64N7O17P3S, cytosol
- 2 Fe(3+)Cb5CHEBI:18097, cytosol
- 2 H2OCHEBI:15377, H2O, cytosol
Catalysed by
- stearoyl-CoA 9-desaturase activity of SCD dimer [endoplasmic reticulum membrane]EC 1.14.19.1
Literature
- Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues Int J Cancer, 1994
- Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites Biochem. J., 1999
- Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells Biochem. J., 2005