Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PTGS2 dimer binds PTGS2 inhibitors

PTGS2 dimer + PTGS2 inhibitors → PTGS2 dimer:PTGS2 inhibitors

Reactome: R-HSA-2309779
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

PTGS2 dimerR-HSA-140491, endoplasmic reticulum membrane
PTGS2 inhibitorsR-ALL-9716714, cytosol

Outputs

PTGS2 dimer:PTGS2 inhibitorsR-HSA-2309778, endoplasmic reticulum membrane

Literature

Cyclooxygenases: structural, cellular, and molecular biology Annu Rev Biochem, 2000
Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2 Nat. Struct. Biol., 1996
Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer J. Biol. Chem., 2011