Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA
THA-CoA + O2 → delta2-THA-CoA + H2O2
- Reactome
- R-HSA-2066787
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:39120
Inputs
- THA-CoACHEBI:63540, C45H70N7O17P3S, peroxisomal matrix
- O2CHEBI:15379, O2, peroxisomal matrix
Outputs
- delta2-THA-CoACHEBI:65139, C45H68N7O17P3S, peroxisomal matrix
- H2O2CHEBI:16240, H2O2, peroxisomal matrix
Catalysed by
- acyl-CoA oxidase activity of ACOX1 dimer [peroxisomal matrix]EC 1.3.3.6
Literature
- Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid J Lipid Res, 1995
- Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid J Lipid Res, 2001
- Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis J Biol Chem, 2001