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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH

Ac-CoA + acyl-CoA → 3OA-CoA + CoA-SH

Reactome: R-HSA-8874745
Compartment: mitochondrial matrix
Rhea: RHEA:21565

Inputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
acyl-CoACHEBI:58342, C22H31N7O17P3SR, mitochondrial matrix

Outputs

3OA-CoACHEBI:57347, C24H33N7O18P3SR, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

acetyl-CoA C-acyltransferase activity of ACAA2 tetramer [mitochondrial matrix]EC 2.3.1.16

Literature

Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase Biochim. Biophys. Acta, 1993
The oxoacyl-coenzyme A thiolases of animal tissues Biochem. J., 1973