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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TXA2 is hydrolysed to TXB2

TXA2 + H2O → TXB2

Reactome: R-HSA-443894
Compartment: endoplasmic reticulum lumen
Rhea: None recorded

Inputs

TXA2CHEBI:57445, C20H31O5, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Outputs

TXB2CHEBI:90696, C20H33O6, endoplasmic reticulum lumen

Literature

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides Proc Natl Acad Sci U S A, 1975
Substrate binding is the rate-limiting step in thromboxane synthase catalysis J Biol Chem, 2001