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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MCAT transfers Mal from Mal-CoA to NDUFAB1

Malonyl-CoA + NDUFAB1 → Mal-PPANT-S112-NDUFAB1 + CoA-SH

Reactome: R-HSA-8933547
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

Malonyl-CoACHEBI:57384, C24H33N7O19P3S, mitochondrial matrix
NDUFAB1R-HSA-163925, mitochondrial inner membrane

Outputs

Mal-PPANT-S112-NDUFAB1R-HSA-8934586, mitochondrial inner membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

[acyl-carrier-protein] S-malonyltransferase activity of MCAT [mitochondrial matrix]EC 2.3.1.39; UniProt Q8IVS2

Literature

Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein J. Biol. Chem., 2003