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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Arachidonate is oxidised to 12S-HpETE by ALOX12/15

AA + O2 → 12S-HpETE

Reactome: R-HSA-2161964
Compartment: cytosol
Rhea: RHEA:10429

Inputs

AACHEBI:32395, C20H31O2, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

12S-HpETECHEBI:57444, C20H31O4, cytosol

Catalysed by

arachidonate 12(S)-lipoxygenase activity of ALOX12/15 [cytosol]EC 1.13.11.31

Literature

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase Proc Natl Acad Sci U S A, 1990
Cloning of the cDNA for human 12-lipoxygenase Proc Natl Acad Sci U S A, 1990
Overexpression, purification and characterization of human recombinant 15-lipoxygenase Biochim Biophys Acta, 1993
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related J Biol Chem, 1990