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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

H2O + AA-PC → AA + H+ + LysoPtdCho

Reactome: R-HSA-111883
Compartment: endoplasmic reticulum membrane · cytosol · endoplasmic reticulum lumen
Rhea: RHEA:40652, RHEA:40651

Inputs

H2OCHEBI:15377, H2O, cytosol
AA-PCCHEBI:75063, C29H49NO8PR, endoplasmic reticulum membrane

Outputs

AACHEBI:32395, C20H31O2, cytosol
H+CHEBI:15378, H, cytosol
LysoPtdChoCHEBI:58168, C9H19NO7PR, endoplasmic reticulum membrane

Catalysed by

A2-type glycerophospholipase activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]EC 3.1.1.4

Literature

Functional characterization of mutations in inherited human cPLA? deficiency Biochemistry, 2011
Secreted phospholipase A2 revisited J. Biochem., 2011