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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CPT2 converts acylcarnitine to acyl-CoA

CoA-SH + C8-C18 Acyl-CAR → CAR + C8-C18 Acyl-CoA

Reactome: R-HSA-200410
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:12663, RHEA:40281

Inputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
C8-C18 Acyl-CARR-ALL-9971105, mitochondrial matrix

Outputs

CARCHEBI:16347, C7H15NO3, mitochondrial matrix
C8-C18 Acyl-CoAR-ALL-9971103, mitochondrial matrix

Catalysed by

carnitine O-acyltransferase activity of CPT2 [mitochondrial inner membrane]EC 2.3.1; UniProt P23786

Literature

Carnitine palmitoyltransferase II deficiency: structure of the gene and characterization of two novel disease-causing mutations Hum Mol Genet, 1995
Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling Biochim Biophys Acta, 2010