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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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ACLY tetramer binds ETC-1002-CoA

ACLY tetramer + ETC-1002-CoA → ACLY tetramer:ETC-1002-CoA

Reactome
R-HSA-9734540
Compartment
cytosol
Rhea
None recorded

Inputs

Outputs

Literature

  1. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism J Lipid Res, 2013
  2. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis Nat Commun, 2016