ACLY tetramer binds ETC-1002-CoA
ACLY tetramer + ETC-1002-CoA → ACLY tetramer:ETC-1002-CoA
- Reactome
- R-HSA-9734540
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- ACLY tetramerR-HSA-76188, cytosol
- ETC-1002-CoAR-ALL-9734541, cytosol
Outputs
- ACLY tetramer:ETC-1002-CoAR-HSA-9734534, cytosol
Literature
- AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism J Lipid Res, 2013
- Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis Nat Commun, 2016