Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA

bempedoic acid + CoA-SH + ATP → ETC-1002-CoA + AMP + PPi

Reactome: R-HSA-9734535
Compartment: cytosol
Rhea: None recorded

Inputs

bempedoic acidR-ALL-9734538, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

ETC-1002-CoAR-ALL-9734541, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]EC 6.2.1.3; UniProt O14975

Literature

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis Nat Commun, 2016