Arachidonate is hydroxylated to 20-HETE by CYP(3)
AA + O2 + NADPH + H+ → 20-HETE + NADP+ + H2O
- Reactome
- R-HSA-2161940
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen
- Rhea
- RHEA:39756
Inputs
- AACHEBI:32395, C20H31O2, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Outputs
- 20-HETECHEBI:76624, C20H31O3, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of CYP(3) [endoplasmic reticulum membrane]
Literature
- Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension Circulation, 2005
- Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11 J Pharmacol Exp Ther, 1998
- Prostaglandin and leukotriene omega-hydroxylases Prostaglandins Other Lipid Mediat, 2002
- CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids J Biol Chem, 2004
- Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Drug Metab Dispos, 2004