2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
3S2HPhy-CoA → Pristanal + FOR-CoA
- Reactome
- R-HSA-389611
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:25356
Inputs
- 3S2HPhy-CoACHEBI:57334, C41H70N7O18P3S, peroxisomal matrix
Outputs
- PristanalCHEBI:49189, C19H38O, peroxisomal matrix
- FOR-CoACHEBI:57376, C22H32N7O17P3S, peroxisomal matrix
Catalysed by
- carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix]EC 4.1
Literature
- Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids Proc Natl Acad Sci U S A, 1999
- Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids FEBS Lett, 1997