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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA

3S2HPhy-CoA → Pristanal + FOR-CoA

Reactome
R-HSA-389611
Compartment
peroxisomal matrix
Rhea
RHEA:25356

Inputs

  • 3S2HPhy-CoACHEBI:57334, C41H70N7O18P3S, peroxisomal matrix

Outputs

Catalysed by

  • carbon-carbon lyase activity of HACL1 tetramer [peroxisomal matrix]EC 4.1

Literature

  1. Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids Proc Natl Acad Sci U S A, 1999
  2. Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids FEBS Lett, 1997