Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA
TTA-CoA + O2 + 2 NADH → TPA-CoA + 2 H2O + 2 NAD+
- Reactome
- R-HSA-2046097
- Compartment
- endoplasmic reticulum lumen · endoplasmic reticulum membrane
- Rhea
- None recorded
Inputs
- TTA-CoACHEBI:63548, C45H74N7O17P3S, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
- 2 NADHCHEBI:57945, C21H27N7O14P2, endoplasmic reticulum lumen
Outputs
- TPA-CoACHEBI:74084, C45H68N7O17P3S, endoplasmic reticulum lumen
- 2 H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- 2 NAD+CHEBI:57540, C21H26N7O14P2, endoplasmic reticulum lumen
Catalysed by
- acyl-CoA 6-desaturase activity of FADS2 [endoplasmic reticulum membrane]EC 1.14.19.3; UniProt O95864
Literature
- The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase J Biol Chem, 1991
- The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis Biochem J, 2002