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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SCD5 desaturates ST-CoA to OLE-CoA

ST-CoA + 2 H+ + O2 + 2 Fe(2+)Cb5 → OLE-CoA + 2 Fe(3+)Cb5 + 2 H2O

Reactome: R-HSA-8847579
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:19722

Inputs

ST-CoACHEBI:57394, C39H66N7O17P3S, cytosol
2 H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol
2 Fe(2+)Cb5CHEBI:16518, cytosol

Outputs

OLE-CoACHEBI:57387, C39H64N7O17P3S, cytosol
2 Fe(3+)Cb5CHEBI:18097, cytosol
2 H2OCHEBI:15377, H2O, cytosol

Catalysed by

stearoyl-CoA 9-desaturase activity of SCD5 dimer [endoplasmic reticulum membrane]EC 1.14.19.1

Literature

Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates Biochem. Biophys. Res. Commun., 2005
Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells Biochem. J., 2005