Peroxisomal uptake of very long-chain fatty acyl CoA
VLCFA-CoA + 2 H2O + ATP → VLCFA + ADP + CoA-SH + 2 H+
- Reactome
- R-HSA-390393
- Compartment
- peroxisomal membrane
- Rhea
- RHEA:67073, RHEA:67081
Inputs
- VLCFA-CoACHEBI:138261, C22H31N7O17P3SR, cytosol
- 2 H2OCHEBI:15377, H2O, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- VLCFACHEBI:58950, CO2R, peroxisomal matrix
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
- 2 H+CHEBI:15378, H, cytosol
Catalysed by
- ATPase-coupled transmembrane transporter activity of ABCD1 homodimer [peroxisomal membrane]EC 7.2.2
Literature
- Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation Biochim Biophys Acta, 2011
- Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes Sci Rep, 2021
- Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae J Biol Chem, 2012