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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome

Malonyl-CoA + H+ → Ac-CoA + CO2

Reactome: R-HSA-977317
Compartment: peroxisomal matrix
Rhea: RHEA:18782

Inputs

Malonyl-CoACHEBI:57384, C24H33N7O19P3S, peroxisomal matrix
H+CHEBI:15378, H, peroxisomal matrix

Outputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, peroxisomal matrix
CO2CHEBI:16526, CO2, peroxisomal matrix

Catalysed by

malonyl-CoA decarboxylase activity of MLYCD(40-493) [peroxisomal matrix]EC 4.1.1.9; UniProt O95822

Literature

MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency J Biol Chem, 1999