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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Activation of linoleic acid to linoleoyl-CoA

LINA + ATP + CoA-SH → LA-CoA + PPi + adenosine 5'-monophosphate

Reactome: R-HSA-2046098
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: RHEA:33651

Inputs

LINACHEBI:17351, C18H32O2, endoplasmic reticulum lumen
ATPCHEBI:30616, C10H12N5O13P3, endoplasmic reticulum membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen

Outputs

LA-CoACHEBI:57383, C39H62N7O17P3S, endoplasmic reticulum lumen
PPiCHEBI:33019, HO7P2, endoplasmic reticulum membrane
adenosine 5'-monophosphateCHEBI:456215, C10H12N5O7P, endoplasmic reticulum membrane

Catalysed by

long-chain fatty acid-CoA ligase activity of ACSL1 [endoplasmic reticulum membrane]EC 6.2.1.3

Literature

Discovery of an arachidonoyl coenzyme A synthetase in human platelets J Biol Chem, 1982