Translocation of tetracosapentaenoyl-CoA to peroxisomes
ATP + TPA-CoA → ADP + TPA-CoA + Pi
- Reactome
- R-HSA-2046093
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen · peroxisomal membrane · peroxisomal matrix
- Rhea
- None recorded
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, endoplasmic reticulum membrane
- TPA-CoACHEBI:74084, C45H68N7O17P3S, endoplasmic reticulum lumen
Outputs
- ADPCHEBI:456216, C10H12N5O10P2, endoplasmic reticulum membrane
- TPA-CoACHEBI:74084, C45H68N7O17P3S, peroxisomal matrix
- PiCHEBI:43474, HO4P, endoplasmic reticulum membrane
Catalysed by
- long-chain fatty acid transmembrane transporter activity of ABCD1 [peroxisomal membrane]EC 7.6.2.4; UniProt P33897
Literature
- Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids FEBS Lett, 1998
- Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis J Biol Chem, 2001
- Studies on the metabolic fate of n-3 polyunsaturated fatty acids J Lipid Res, 2003