DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA
NADPH + H+ + (2E,4E)-dienoyl-CoA → NADP+ + 4,5-saturated-(3E)-enoyl-CoA(4-)
- Reactome
- R-HSA-6786720
- Compartment
- peroxisomal matrix · peroxisomal membrane
- Rhea
- RHEA:45913
Inputs
- NADPHCHEBI:57783, C21H26N7O17P3, peroxisomal matrix
- H+CHEBI:15378, H, peroxisomal matrix
- (2E,4E)-dienoyl-CoACHEBI:85101, C26H35N7O17P3SR, peroxisomal matrix
Outputs
- NADP+CHEBI:58349, C21H25N7O17P3, peroxisomal matrix
- 4,5-saturated-(3E)-enoyl-CoA(4-)CHEBI:85493, C26H37N7O17P3SR, peroxisomal matrix
Catalysed by
- trans-2-enoyl-CoA reductase (NADPH) activity of DECR2 [peroxisomal membrane]EC 1.3.1.38; UniProt Q9NUI1
Literature
- Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase Biochim. Biophys. Acta, 2001
- Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids J. Biol. Chem., 2012