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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE

5-HETEL + H2O → 5-HETE

Reactome: R-HSA-8932633
Compartment: extracellular region
Rhea: None recorded

Inputs

5-HETELCHEBI:132873, C20H38O2, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

5-HETECHEBI:65341, C20H31O3, extracellular region

Catalysed by

acyl-L-homoserine-lactone lactonohydrolase activity of PON1,2,3:2xCa2+ dimers [extracellular region]EC 3.1.1.81

Literature

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities J. Lipid Res., 2005
Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases Methods Mol. Biol., 2008