Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
ALA-CoA + O2 + 2 NADH → SDA-CoA + 2 H2O + 2 NAD+
- Reactome
- R-HSA-2046084
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen
- Rhea
- None recorded
Inputs
- ALA-CoACHEBI:51985, C39H64N7O17P3S, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
- 2 NADHCHEBI:57945, C21H27N7O14P2, endoplasmic reticulum lumen
Outputs
- SDA-CoACHEBI:63545, C39H62N7O17P3S, endoplasmic reticulum lumen
- 2 H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- 2 NAD+CHEBI:57540, C21H26N7O14P2, endoplasmic reticulum lumen
Catalysed by
- acyl-CoA 6-desaturase activity of FADS2 [endoplasmic reticulum membrane]EC 1.14.19.3; UniProt O95864
Literature
- Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity J Invest Dermatol, 2003
- Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element J Lipid Res, 2003
- Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats Biochim Biophys Acta, 1992
- The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis Biochem J, 2002
- Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits J Nutr, 2009