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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

15S-HETE is oxidised to 15-oxoETE by 15-HEDH

15S-HETE + NAD(P)+ → 15-oxoETE + NAD(P)H + H+

Reactome: R-HSA-2161789
Compartment: cytosol
Rhea: RHEA:23261, RHEA:23265, RHEA:23260, RHEA:23264

Inputs

15S-HETECHEBI:57409, C20H31O3, cytosol
NAD(P)+R-ALL-428218, cytosol

Outputs

15-oxoETECHEBI:57410, C20H29O3, cytosol
NAD(P)HR-ALL-428206, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

15-hydroxyicosatetraenoate dehydrogenase activity of 15-HEDH [cytosol]EC 1.1.1.232

Literature

Expression of 15-lipoxygenase type-1 in human mast cells Biochim Biophys Acta, 2007