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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGG2 is reduced to PGH2 by PTGS2

PGG2 + hydrogen donor → H2O + PGH2 + hydrogen acceptor

Reactome: R-HSA-2309773
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: RHEA:42601, RHEA:42600

Inputs

PGG2CHEBI:82629, C20H31O6, endoplasmic reticulum lumen
hydrogen donorCHEBI:17499, H2A, endoplasmic reticulum lumen

Outputs

H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
PGH2CHEBI:57405, C20H31O5, endoplasmic reticulum lumen
hydrogen acceptorCHEBI:13193, A, endoplasmic reticulum lumen

Catalysed by

peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]EC 1.11.1.7

Literature

Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis Proc Natl Acad Sci U S A, 1973
Human cyclooxygenase-2 cDNA Proc Natl Acad Sci U S A, 1992
Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid J Biol Chem, 1997
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system Biochim Biophys Acta, 1994