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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA

DPA-CoA + Malonyl-CoA + 2 NADPH → TPA-CoA + CO2 + CoA-SH + H2O + 2 NADP+

Reactome
R-HSA-2046090
Compartment
endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea
None recorded

Inputs

  • DPA-CoACHEBI:63541, C43H68N7O17P3S, endoplasmic reticulum lumen
  • Malonyl-CoACHEBI:57384, C24H33N7O19P3S, endoplasmic reticulum lumen
  • 2 NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen

Outputs

  • TPA-CoACHEBI:63543, C45H72N7O17P3S, endoplasmic reticulum lumen
  • CO2CHEBI:16526, CO2, endoplasmic reticulum lumen
  • CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen
  • H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
  • 2 NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

Literature

  1. Elongation of long-chain fatty acids Prog Lipid Res, 2004
  2. The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase J Biol Chem, 1991