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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PTGS1,2 dimers bind PTGS Inhibitors

PTGS1 dimer + PTGS inhibitors + PTGS2 dimer → PTGS1 dimer:PTGS Inhibitors + PTGS2 dimer:PTGS inhibitors

Reactome: R-HSA-9716838
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

PTGS1 dimerR-HSA-428986, endoplasmic reticulum membrane
PTGS inhibitorsR-ALL-9716837, cytosol
PTGS2 dimerR-HSA-140491, endoplasmic reticulum membrane

Outputs

PTGS1 dimer:PTGS InhibitorsR-HSA-9716834, endoplasmic reticulum membrane
PTGS2 dimer:PTGS inhibitorsR-HSA-9716835, endoplasmic reticulum membrane

Literature

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nature New Biol., 1971
Mechanism of action of aspirin-like drugs Semin. Arthritis Rheum., 1997
Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs Am. J. Med., 1998
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis Proc. Natl. Acad. Sci. U.S.A., 1999
Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System Clin Pharmacol Ther, 2017