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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA

trans-2,3-dehydrohexacosanoyl-CoA + H2O → 3-hydroxyhexacosanoyl-CoA

Reactome
R-HSA-390252
Compartment
peroxisomal matrix
Rhea
RHEA:39213

Inputs

  • trans-2,3-dehydrohexacosanoyl-CoACHEBI:74281, C47H80N7O17P3S, peroxisomal matrix
  • H2OCHEBI:15377, H2O, peroxisomal matrix

Outputs

  • 3-hydroxyhexacosanoyl-CoACHEBI:76378, C47H82N7O18P3S, peroxisomal matrix

Catalysed by

  • 3-hydroxyacyl-CoA dehydratase activity of HSD17B4 dimer [peroxisomal matrix]EC 4.2.1.150

Literature

  1. Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis Am J Hum Genet, 2006
  2. Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase J Biochem (Tokyo), 1996
  3. Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein J Biochem, 1997