Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Arachidonate is epoxidated to 5,6-EET by CYP(4)

AA + O2 + NADPH + H+ → 5,6-EET + NADP+ + H2O

Reactome: R-HSA-2161890
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:49937

Inputs

AACHEBI:32395, C20H31O2, cytosol
O2CHEBI:15379, O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

5,6-EETCHEBI:131992, C20H31O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

monooxygenase activity of CYP(4) [endoplasmic reticulum membrane]

Literature

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Drug Metab Dispos, 2004
Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart J Biol Chem, 1996