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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Arachidonate is hydroxylated to 18-HETE by CYP(1)

AA + O2 + NADPH + H+ → NADP+ + H2O + 18-HETE

Reactome: R-HSA-9915993
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: RHEA:39812

Inputs

AACHEBI:32395, C20H31O2, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen

Outputs

NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
18-HETECHEBI:63590, C20H31O3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of CYP(1) [endoplasmic reticulum membrane]

Literature

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 Drug Metab Dispos, 2004