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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA

DGL-CoA + O2 + 2 NADH → AA-CoA + 2 H2O + 2 NAD+

Reactome
R-HSA-2046092
Compartment
endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea
None recorded

Inputs

  • DGL-CoACHEBI:27979, C41H68N7O17P3S, endoplasmic reticulum lumen
  • O2CHEBI:15379, O2, endoplasmic reticulum lumen
  • 2 NADHCHEBI:57945, C21H27N7O14P2, endoplasmic reticulum lumen

Outputs

  • AA-CoACHEBI:57368, C41H62N7O17P3S, endoplasmic reticulum lumen
  • 2 H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
  • 2 NAD+CHEBI:57540, C21H26N7O14P2, endoplasmic reticulum lumen

Catalysed by

  • omega-6 fatty acid desaturase activity of FADS1 [endoplasmic reticulum membrane]UniProt O60427

Literature

  1. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase J Biol Chem, 1999
  2. cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid Biochem J, 2000