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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

PALM-CoA + Mal-CoA + H+ → 3OOD-CoA + CoA-SH + CO2

Reactome: R-HSA-548814
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:35316

Inputs

PALM-CoACHEBI:57379, C37H62N7O17P3S, cytosol
Mal-CoACHEBI:57384, C24H33N7O19P3S, cytosol
H+CHEBI:15378, H, cytosol

Outputs

3OOD-CoACHEBI:71407, C39H64N7O18P3S, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
CO2CHEBI:16526, CO2, cytosol

Catalysed by

fatty acid elongase activity of ELOVL3,6,7 [endoplasmic reticulum membrane]EC 2.3.1.199

Literature

Identification and characterization of a selective radioligand for ELOVL6 J Biochem, 2009
Biochemical characterization of the very long-chain fatty acid elongase ELOVL7 FEBS Lett., 2011
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis Proc Natl Acad Sci U S A, 2010