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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

Btn-ACACB:2Mn2+ polymer + ATP → Btn-p-S222-ACACB:2Mn2+ polymer + ADP + H+

Reactome: R-HSA-200423
Compartment: cytosol · mitochondrial outer membrane
Rhea: RHEA:17990

Inputs

Btn-ACACB:2Mn2+ polymerR-HSA-8867341, mitochondrial outer membrane
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

Btn-p-S222-ACACB:2Mn2+ polymerR-HSA-8876893, mitochondrial outer membrane
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

AMP-activated protein kinase activity of AMPK heterotrimer (active) [cytosol]EC 2.7.11.1

Literature

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome Nat Rev Drug Discov, 2004