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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA

DTA-CoA + Malonyl-CoA + 2 NADPH → TTA-CoA + CO2 + CoA-SH + H2O

Reactome: R-HSA-2046095
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

DTA-CoACHEBI:63544, C43H70N7O17P3S, endoplasmic reticulum lumen
Malonyl-CoACHEBI:57384, C24H33N7O19P3S, endoplasmic reticulum lumen
2 NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen

Outputs

TTA-CoACHEBI:63548, C45H74N7O17P3S, endoplasmic reticulum lumen
CO2CHEBI:16526, CO2, endoplasmic reticulum lumen
CoA-SHCHEBI:57287, C21H32N7O16P3S, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Catalysed by

fatty acid elongase activity of ELOVL2 [endoplasmic reticulum membrane]EC 2.3.1.199; UniProt Q9NXB9

Literature

The biosynthesis of delta-9,12,15,18-tetracosatetraenoic and of delta-6,9,12,15,18-tetracosapentaenoic acids by rat testes J Biol Chem, 1970
Elongation of long-chain fatty acids Prog Lipid Res, 2004
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles J Lipid Res, 1973