PGD2 is reduced to 11-epi-PGF2a by AKRIC3
PGD2 + H+ + NADPH → 11epi-PGF2a + NADP+
- Reactome
- R-HSA-2161614
- Compartment
- cytosol
- Rhea
- RHEA:45317
Inputs
- PGD2CHEBI:57406, C20H31O5, cytosol
- H+CHEBI:15378, H, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
Outputs
- 11epi-PGF2aCHEBI:85173, C20H33O5, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Catalysed by
- prostaglandin D2 11-ketoreductase activity of AKR1C3 [cytosol]EC 1.1.1.188; UniProt P42330
Literature
- Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans Proc Natl Acad Sci U S A, 1985
- Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS Arch Biochem Biophys, 2004
- Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer J Steroid Biochem Mol Biol, 2010