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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA

3-Oxopalmitoyl-CoA + CoA-SH → MYS-CoA + Ac-CoA

Reactome: R-HSA-77304
Compartment: mitochondrial matrix
Rhea: RHEA:18163

Inputs

3-Oxopalmitoyl-CoACHEBI:57349, C37H60N7O18P3S, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

MYS-CoACHEBI:57385, C35H58N7O17P3S, mitochondrial matrix
Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix

Catalysed by

acetyl-CoA C-acyltransferase activity of Trifunctional Protein [mitochondrial matrix]EC 2.3.1.16

Literature

Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria. Biochem Biophys Res Commun, 1992