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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA

MCFA-CoA, LCFA-CoA + H2O → MCFA, LCFA + CoA-SH + H+

Reactome: R-HSA-5690043
Compartment: cytosol
Rhea: RHEA:68185, RHEA:67681

Inputs

MCFA-CoA, LCFA-CoAR-ALL-5690044, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

MCFA, LCFAR-ALL-5690064, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

fatty acyl-CoA hydrolase activity of Cytosolic ACOTs, THEM4 [cytosol]EC 3.1.2.20

Literature

New players on the metabolic stage: How do you like Them Acots? Adipocyte, 2013
The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism Biochim. Biophys. Acta, 2012
Functional and structural properties of mammalian acyl-coenzyme A thioesterases Prog. Lipid Res., 2010
Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs FASEB J., 2006
Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain J. Biol. Chem., 2014
Crystal structure of human thioesterase superfamily member 2 Biochem. Biophys. Res. Commun., 2006